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KMID : 0370220140580010012
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Yakhak Hoeji
2014 Volume.58 No. 1 p.12 ~ p.15
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Inhibition of Nitric Oxide Production by Stilbenes from Polygonum cuspidatum
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Joo Si-Mong
Hong Yun-Jung
Yang Ki-Sook
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Abstract
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Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea, favus athlete’s foot, hyperlipidemia and inflammation in traditional medicine. We examined anti-oxidant and antiinflammatory activity by measuring DPPH radical scavenging activity and the inhibition of IFN-γ and LPS-induced NO production in RAW 264.7 murine macrophage cells. We isolated and characterized resveratrol (1), trans-resveratrol 3-O-β-Dglucopyranoside
(2). Compounds 1 and 2 showed potent activities compared with L-NMMA (NG-monomethyl-L-arginine). These results suggested that the stilbene compounds isolated from Polygonum cuspidatum might be used as antiinflammatory agents.
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KEYWORD
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Polygonum cuspidatum, resveratrol, trans-resveratrol 3-O-β-D-glucopyranoside, antiinflammatory agents
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